Dr. Jess Shisler, Founder, Scientist, Operator SOM Aesthetics · Encinitas, CA
About Jess

Science taught me to prove hypotheses. Business taught me to prove people wrong.

I'm a 4× founder, PhD biochemist, and former NIH postdoc who walked out of the lab and into a decade of building companies across sectors most people wouldn't combine: one venture-backed at a $20M+ valuation, one generating millions in annual revenue, one a media business built from a van. The scientific rigor never left. It just found better problems to solve.

PhD Biochemistry · U of Minnesota NIH Postdoctoral Fellow 4× Founder Techstars Mentor $3.3M Raised · $20M+ Valuation

I didn't take the expected path. That turned out to be the point.

After a PhD in Biochemistry at the University of Minnesota and a postdoctoral fellowship at the NIH, studying how diet and genetics shape aging and healthspan, I walked away from academic science. Not because the work wasn't important. Because the institution moved too slowly, and I couldn't stop thinking about building things.

I brought the same rigor I'd used to design experiments to building companies: test assumptions fast, kill what doesn't work, double down on what does. The scientific method and the startup method are the same method. Most founders just don't know they're using it.


From science translation to outdoor tech to medical aesthetics.

Science communications wasn't an established field when I entered it. I joined Spectrum Science in DC to help build it, then founded Decode Communications to run my own practice. What I learned across both: the gap between knowledge and action is almost never about information. It's about framing, trust, and timing.

Then came Sēkr, an outdoor travel platform I co-founded and built as COO. We raised $3.3M at a $20M+ valuation, built a team, and learned more about product-market fit, co-founder dynamics, and the reality of venture funding than any business school case study could capture. Alongside that, I co-founded Project Respect Outdoors, a community for women in the outdoor space.

After Sēkr, I founded SOM Aesthetics, a concierge dermatology and medical spa in Encinitas, CA. I still design clinical studies and run the business. Different industry, same instinct: figure out what's actually true about your customer, then move faster than anyone expects.


The van. The land. The through-line.

From 2017 to 2022, I lived and worked nomadically in a self-converted Sprinter van, building companies from national forests, desert highways, and coastal campsites. Documented the whole thing under @van.there on Instagram. The conversation was never really about the van. It was about how intentionally you design your life. About proving that freedom and productivity aren't opposites. That you don't have to sacrifice one life to build another.

In 2022, I bought 10 acres in Temecula wine country, currently off-grid, with plans to build eventually. Now based in Encinitas, where SOM Aesthetics also lives. The van is parked. The idea behind it isn't: you get to decide what your life looks like. Most people never stop to question whether the default version is the one they actually want. That question is what every company I've built has been trying to answer, in one form or another.

Career arc

Not your average career path.

2006–2011
PhD, Biochemistry
University of Minnesota

Researched how diet and genetics lead to mitochondrial dysfunction in the fat cell. Trained in the discipline of proving things rather than asserting them. The scientific method became the only framework I'd ever need.

2011–2013
Postdoctoral Fellow
NIH National Institute on Aging

Researched how aging and healthspan were impacted by diet and genetics. Prestigious, meaningful. And increasingly clear that the lab was not where I was meant to stay.

2013–2017
Scientific Advisor, Spectrum Science
Strategic communications · Pharma & Biotech

Advised major pharma and biotech clients on science strategy and communications. Worked on AbbVie's Immunology and R&D portfolio, including the launch of Humira across three indications and the launch of Skyrizi, as well as Bristol Myers Squibb R&D, P&G, and others.

2017–Present
Founder, Decode Communications
Science translation + strategic communications

Known as “the CEO whisperer”: embedded science comms advisor to CEO scientists who needed to communicate complex science to investors, regulators, and the public. Built a consultancy translating the hardest ideas in pharma and biotech into language that moves people to act. Expanded the client base into AI-driven drug development, including 1910 Genetics and Gen1e Lifesciences.

2017–2022
Van.There
Lifestyle media · Content creator · @van.there

Built a content brand around a simple idea: you get to design your life. Five years living and working nomadically in a self-converted Sprinter van, documenting what it looks like to build intentionally instead of by default. The van was the medium. The message was that how you structure your life is as important as what you build in it. That turned into a business, a community, and an audience that followed the philosophy as much as the adventure.

2018–2022
Co-Founder & COO, Sēkr
Outdoor travel platform · Raised $3.3M · $20M+ valuation

Built an outdoor travel and campsite discovery platform with my co-founder from the ground up: product, team, fundraise, and all the co-founder dynamics that come with it. Raised $3.3M at a $20M+ valuation. Learned things that required raising $3.3M to learn.

2020
Techstars Anywhere Accelerator
Founder · Techstars Anywhere

Went through Techstars as a founder. The closest thing to an MBA I've experienced, compressed into 13 weeks: fundraising mechanics, investor dynamics, go-to-market strategy, and how to make high-stakes decisions before you have enough data. The accountability structure alone was worth it. Later became a mentor for other Techstars programs, paying forward what the program gave me.

2023–Present
Founder, SOM Aesthetics
Concierge dermatology + medical spa · Encinitas, CA

Built a concierge dermatology and medical spa from the ground up. What changes between industries is the vocabulary. What doesn't: the customer problem, the unit economics, and the discipline of testing your assumptions. I still design and run clinical studies alongside the business.

"The basics of building don't change between industries. The market changes. The customer changes. The vocabulary definitely changes. But the discipline of testing assumptions, building systems, and making decisions before you have enough data? That transfers. Every time."

— Jess Shisler PhD

Women founders working at whiteboard
How I think

Anti-coaching. Pro-building.

There's a lot of advice out there. Some of it is even good. The harder problem is knowing which advice is relevant to your business—and that judgment only comes from someone who actually knows it. Most advisors hand you a framework and step back. I get into the specifics: the actual constraints, the real decision, the assumption that's quietly killing your momentum. That's what makes advice actionable instead of just interesting.

My philosophy is borrowed from the lab: you can't theorize your way to a result. You have to run the experiment. The fastest path forward is to identify the assumption that, if wrong, kills the whole thing. Then go test it before you invest another dollar or another year in being wrong.

I work with founders who are building things that don't fit neat categories, in ways that people around them have been skeptical of. I know that position well. It tends to produce the most interesting outcomes.

You don't need a coach. You need someone who's built this before. Bring the vision. I'll bring the blueprint.

From the Field Notes

Writing that tells more of the story.

Ready to stop planning and start building?

If you're working on something that doesn't fit a neat category, you're probably in the right place.