Founder · Scientist · Operator

Build smarter businesses.
Take bigger risks.

A multi-time founder and proven operator turning ideas into million-dollar businesses. PhD biochemist, Techstars alum, and mentor to the next generation of builders. I've spent my career ignoring what women in my position were "supposed to do" — and helping others do the same.

Work with me My story

Think like a scientist

Most business decisions get made on gut feel. I bring PhD-trained rigor to strategy: frameworks for testing assumptions, cutting noise, and making better calls with the information you actually have.

AI business tools

I run two businesses with AI and I'll show you exactly how. The tools that work, the workflows that stick, and the hours you get back. No hype, no theory.

Build bolder

How the safe choice can be the most expensive. I help founders and operators recognize which risks are worth taking and make moves they didn't think were available to them.

Dr. Jess Shisler — Founder, Scientist, Operator

About

Science taught me to prove hypotheses. Business taught me to prove people wrong.

I spent seven years in research science, earning credentials that were supposed to set my course. Then I left — because I trusted I could build something more impactful, even if it was unconventional.

From my NIH fellowship, to consulting from a self-built Sprinter van, to co-founding a venture-backed startup, then launching a medical aesthetics brand — each step looked risky from the outside and inevitable from the inside.

After building three companies and raising over $4 million across biotech, consumer tech, and medical aesthetics, what I've learned is that the only thing separating you from where you want to be is your willingness to keep going.

Full story →

4×

Founder & COO

PhD

Biochemistry

NIH

Postdoctoral Fellow

Techstars

Alum & Mentor

Strategy Session

A focused 90-minute engagement on your most urgent problem — operations, go-to-market, fundraising, or AI implementation. You leave with a clear, executable plan.

Advisory Retainer

Ongoing monthly partnership for founders who need a strategic operator in their corner. I embed in your business — not just your inbox. Built for zero-to-one and scale-up stages.

Speaking

Keynotes, panels, and workshops on AI in business, women in entrepreneurship, and building non-linear careers. Actionable — not inspirational. I don't do motivation. I do execution.

Collaboration

Podcast guest spots, co-created content, brand partnerships, and joint appearances. If your audience overlaps with mine — founders, operators, women building real businesses — let's talk about what we can make together.